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Stress and Cortisol Production
Cortisol is produced in and secreted by the adrenal glands in response to control signals from the pituitary gland and hypothalamus of the brain.
While cortisol itself has many important functions for the body including regulation of metabolism and blood pressure, its role in the bodily stress response has earned it the nickname of "stress hormone."
Cortisol secretion is increased in response to physical and psychological stress of any kind. When the stressful event or situation is over, cortisol levels return to normal.
Interestingly, doctors have shown that in both depressed adults and children, the hypothalamic-pituitary-adrenal axis activity is increased, leading to continually elevated levels of cortisol.
This situation is similar to that seen in persons experiencing chronic stress, who may also have sustained higher-than-normal levels of cortisol.
While prolonged increases in cortisol levels can lead to changes in mood, a causal relationship between elevated cortisol levels and depression has not been firmly established.
Clinical depression is a complex condition likely resulting from a combination of inherited, biochemical, and environmental factors.
Elevation of cortisol through a prolonged stress response is only one factor that may be related to the mood changes associated with depression.
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